Hyperkeratosis lenticularis perstans vs solar keratosis, he 20x 23. Hyperkeratosis lenticularis perstans also known as flegels disease is a keratinisation disorder characterized by small keratotic papules. A case of flegels disease, or hyperkeratosis lenticularis perstans, is reported. Prognosis hyperkeratosis lenticularis perstans not supplied.
Flegel disease is also known as hyperkeratosis lenticularis perstans. Hyperkeratosis lenticularis persians, international journal. We report on new immunohistochemical and ultrastructural findings suggesting a complex disorder of epidermal differentiation. A case of infantile kyrleflegel disease in a 6yearold yemeni girl.
Hyperkeratosis lenticularis perstans of flegel, he 60x 14187 flegels disease. If you have hyperkerafosis concerns with your skin or its treatment, see a dermatologist for advice. Dermoscopy of hyperkeratosis lenticularis perstans flegel disease. Most cases have been reported in europe with age of presentation between 35 and 60 years. There was a problem providing the content you requested. There may be some relationship between genes participating in oncogenesis and hlp genes.
Consanguinity has been observed in onethird of the cases described 5, 8. Six members of his family have died of cancers of the stomach, liver, and colon. Pdf on mar 1, 20, krina b patel and others published hyperkeratosis lenticularis perstans. Hyperkeratosis lenticularis perstans flegel disease likely has both a familial and nonfamilial variant, since several reports have postulated both an autosomal dominant and a sporadic mode of inheritance. Hyperkeratosis excessive development of the corneous layer of the skin in humans. Deficiencies of vitamins a and e, b complex vitamins, and essential fatty acids have all been implicated in the etiology. Hyperkeratosis is manifested by the formation of horny plates, nodes of various sizes, protuberances, and spurs. Antonio bazzini free sheet music to download in pdf. Hyperkeratosis lenticularis perstans hlp or flegels disease is a rare. Flegel originally described hyperkeratosis lenticularis perstans hlp in 1958 as redbrown papules with horny scales of irregular outline measuring 15 mm in diameter and up to 1 mm in depth. Click on the link to view a sample search on this topic. Discussion hyperkeratosis lenticularis perstans is a rare dermatosis first described in.
Lesions are located primarily on the dorsal feet and lower legs, with a. Changes showed sharp demarcation from normal skin, which showed basket weave hyperkeratosis figure 5. Jan 31, 2017 flegel originally described hyperkeratosis lenticularis perstans hlp in 1958 as redbrown papules with horny scales of irregular outline measuring 15 mm in diameter and up to 1 mm in depth. Hyperkeratosis definition of hyperkeratosis by merriam. Hyperkeratosis lenticularis perstans was first described by flegel 1 in 1958. Sep 28, 2012 hyperkeratosis lenticularis perstans also known as flegels disease is a keratinisation disorder characterized by small keratotic papules with horny scales. Hyperkeratosis lenticularis perstans, or flegel disease, with. Find out information about hyperkeratosis lenticularis perstans. The purpose of this study is to show the significant association of squamous metaplasia the precursor for cervical cancer, hyperkeratosis, and parakeratosis, and as the pap smear finding in patients with uterine prolapse, which is sparsely represented in the literature despite the high incidence of the later. Hyperkeratosis in flegels disease jama jama network.
Kyrle disease should exhibit an impressive keratin plug and inflammatory material perforating through the epidermis. Hyperkeratosis lenticularis perstans also known as flegels disease is a keratinisation disorder characterized by small keratotic papules with horny scales. Hyperkeratosis follicularis in cutem penetrans definition. Characteristics include generalized redness of the skin and severe hyperkeratosis with small, hard wartlike scales over the entire body, accentuated in areas that flex or bend and sometimes involving the palms and soles. A clinicopathological study of flegels disease hyperkeratosis lenticularis perstans. Lesions are located primarily on the dorsal feet and lower legs, with a decreasing likelihood of manifestation proximally. Indian j dermatol serial online 20 cited 2020 apr 16. Hyperkeratosis lenticularis perstans flegel disease workup. He termed this condition hyperkeratosis lenticularis perstans, owing to the persistent perstans presence of a disclike central keratinous plug lenticularis.
Hyperkeratosis definition is hypertrophy of the corneous layer of the skin. We describe here the clinical and histological features of two female patients with widespread keratoses affecting the limbs, features which closely resemble those of the patient reported by flegel. Full text full text is available as a scanned copy of the original print version. A corn or callus on your hands or feet is a form of hyperkeratosis. Pubmed is a searchable database of medical literature and lists journal articles that discuss hyperkeratosis lenticularis perstans. Clinical and histopathological correlation confirmed the diagnosis of hyperkeratosis lenticularis perstans hlp or flegels disease. Hyperkeratosis lenticularis perstans symptoms, diagnosis. Patient was prescribed oral vitamin a 5000 iu daily for 15 days, topical tretinoin cream 0. Zinc paste bandages and the treatment of flegels disease. Get a printable copy pdf file of the complete article 83k, or click on a page image below to browse page by page. Hyperkeratosis lenticularis perstans hlp also known as flegel disease, hlp is a cutaneous condition characterised by rough, yellowbrown keratotic, flattopped papules of irregular outline measuring 15mm in diameter and up to 1mm in depth rapini et al, 2007. It may rightly be redefined as an autosomal dominant mucocutaneous syndrome of. Dermoscopy of hyperkeratosis lenticularis perstans flegel disease enzo errichetti marco turina stefano pizzolitto.
Hyperkeratosis lenticularis perstans flegel springerlink. Share the full text of this article with up to 5 colleagues for free. There is a proposed autosomal dominant mode of inheritance, so inquire about a family history. Hyperkeratosis lenticularis perstans article about. Hyperkeratosis lenticularis perstans jama dermatology. Hyperkeratosis lenticularis perstans also known as flegel disease, hyperkeratosis lenticularis perstans is a cutaneous condition characterised by rough, yellowbrown keratotic, flattopped papules of irregular outline measuring 15mm in diameter and up to 1mm in depth 32. Jan 31, 2017 no data exist on incidence or prevalence of this disease. Since 1970, eight patients with hlp have been reported in the japanese literature, but most of the archives readers would not have the opportunity to read the original japanese articles. Kyrle disease this condition is clinically similar and may share some pathogenic components. The information presented here is not intended to diagnose, treat, cure or prevent any disease. Aug 23, 2019 a clinicopathological study of flegels disease hyperkeratosis lenticularis perstans. Hyperkeratosis lenticularis perstans of flegel, he 20x 4255 flegels disease.
The term hyperkeratosis is often used in connection with lesions of the mucous membranes, such as leukoplakia. Familial hyperkeratosis lenticularis perstans, the. She presented with a hard mobile lesion over her nose which was excised. Mar 01, 2020 access to this database is free of charge. Hyperkeratosis lenticularis perstans the free dictionary. We present a case of hyperkeratosis lenticularis perstans flegels disease in a 71yearoldwoman. Electron microscopy of skin lesions from a patient with hyperkeratosis lenticularis perstans showed formation of a compact hyperkeratotic stratum corneum which appears to be related to lack of odland bodies in the underlying epidermis. Read hyperkeratosis lenticularis persians, international journal of dermatology on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Hyperkeratosis lenticularis perstans how is hyperkeratosis. Familial hyperkeratosis lenticularis perstans, the journal of. This rare chronic disorder is characterized by asymptomatic hyperkeratotic papules, usually located on the lower extremities.
Diagnosis hyperkeratosis lenticularis perstans not supplied. Multiple asymptomatic hyperkeratotic papules on the lower part of. It is very similar to kyrle disease and has been regarded as a variant of kyrle disease, however its clinical and pathological. Hyperkeratosis lenticularis perstans was first described by flegel1 in 1958. Differential diagnosis of hyperkeratosis lenticularis perstans flegel disease pathology. Explanation of hyperkeratosis lenticularis perstans. Hyperkeratosis lenticularis perstans hlp flegel disease. Hyperkeratosis definition of hyperkeratosis by the free. These are the options to access the full texts of the publication piel. Hyperkeratosis lenticularis perstans flegel disease. Hyperkeratosis lenticularis perstans flegels disease successful treatment with topical corticosteroids. Hyperkeratosis may be caused by external factors such as prolonged pressure, friction, or the effects of lubricating oils or internal. Confluent and reticulated papillomatosis callus ichthyosis acquisita arsenical keratosis chronic scar keratosis hyperkeratosis lenticularis perstans hydrocarbon keratosis hyperkeratosis of the nipple and areola inverted follicular keratosis lichenoid keratosis multiple. Hyperkeratosis article about hyperkeratosis by the free.
It is characterised by redbrown papules with irregular horny scales located mainly on the top surface of the feet and lower legs. Multiple minute digitate hyperkeratosisa peculiar entity. More detailed information about the symptoms, causes, and treatments of hyperkeratosis lenticularis perstans is available below. Hyperkeratosis lenticularis persians, international. Kyrles hyperkeratosis follicularis et parafollicularis, flegels hyperkeratosis lenticularis perstans, lichen spinulosus, phrynoderma, spiny keratoderma, arsenical keratosis, hyperkeratotic spicules and trichodysplasia spinulosa. Hyperkeratosis lenticularis perstans flegels disease. A rare skin disorder characterized by reddishbrown papules that tend to occur mainly on the lower legs and top part of the feet. Such is their prevalence in the population that community nurses are very likely to encounter unfamiliar dermatological problems during their practice, many of which will have been selftreated for. Hyperkeratosis lenticularis perstans flegels disease is a rare but clinically and histologically highly characteristic genodermatosis. Dermatopathology reference describes hyperkeratosis lenticularis perstans flegel s disease histopathology including histologic features and provides links to additional medical references. The differential diagnosis of pls includes conditions such as hypophosphatasia, histiocytosis x, haim munk.
Hyperkeratosis lenticularis perstans genetic and rare diseases. Familial hyperkeratosis lenticularis perstans associat ed with tumours of the skin. A case of infantile kyrleflegel disease in a 6yearold. Hyperkeratosis lenticularis perstans genetic and rare. Histologically, serial sections of several papules revealed no marked thinning of the epidermis nor severe cell.
Other keratinization disorders can be entertained in the differential diagnosis of digitate keratosis, including. Symptoms of hyperkeratosis lenticularis perstans including 3 medical symptoms and signs of hyperkeratosis lenticularis perstans, alternative diagnoses, misdiagnosis, and correct diagnosis for hyperkeratosis lenticularis perstans signs or hyperkeratosis lenticularis perstans symptoms. Since 1970, eight patients with hlp have been reported in the japanese literature, but most of the archives readers would not have the opportunity to read the original japanese ar. Hyperkeratosis may be accompanied by the formation of painful cracks on the palms and soles. Hyperkeratosis lenticularis perstans also known as flegels disease is a cutaneous condition characterized by rough, yellowbrown keratotic, flattopped papules 639. Hyperkeratosis lenticularis perstans definition of.
1212 749 1214 125 1473 914 480 1118 1148 46 1209 575 1255 930 919 1363 1072 1318 823 1285 462 933 774 1185 232 146 379 1490 796 855 1103 815 1408 568 887 565 1055 609 1020 974